Antibiotics tetronolide compounds and process for production thereof
AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsFusao Tomita, Tatsuya Tamaoki, Kunikatsu Shirahata, Masaji Kasai, Noriaki Hirayama, Makoto Morimoto, Masanori Fukui
Life of this patent
Estimating the term…
Abstract
New antibacterial tetronolide compounds F-1 and F-2 are produced by fermentation of a microorganism belonging to the genus Micromonospora. The antibiotics F-1 and F-2 are accumulated in the culture liquor and are isolated therefrom respectively and the acyl derivatives of F-1 and F-2, that is, F-1-21-O-acetate, F-1-21-O-propionate, F-1-21-O-n-butylate, F-1 diacetate, F-1 dipropionate, F-2 triacetate, F-2 tripropionate and F-2 tri-n-butylate, etc., are synthesized from F-1 and F-2 by known means.
Claims2
A composition of matter having an antibacterial activity which is represented by the formula (1) ##STR8## wherein R.sub.1 and R.sub.2 may be the same or different substituents and represent a hydrogen atom or an acyl group and R.sub.3 represents a hydrogen atom, an acyl group or a tetronitrose represented by the formula (2) ##STR9## and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.