# US 4,393,054 A · Method of treating cardiac arrhythmia

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- Number: US 4,393,054 A
- Document ID: US4393054A
- Status: Granted
- Kind: A
- Application number: 06/379,528
- Filed: 1982-05-19
- Granted: 1983-07-12
- Earliest claimed: 1982-05-19
- Assignees: The Upjohn Company
- Inventors: Harry R. Allen
- Web page: https://patentgrep.com/patent/US4393054A

## CPC

- C07H 19/20: with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)

## Abstract

The 3-(5'-adenylate) of lincomycin- and clindamycin-type compounds in which the propyl hygric acid moiety has been replaced by different cyclic amino acids can be used to treat cardiac arrhythmia in humans and animals.

## Claims

### Claim 1

The method for the treatment of cardiac arrhythmia in a patient which comprises administering a pharmaceutical carrier and a cardiac arrhythmia inhibiting quantity of a compound of the formula
wherein R is ##STR3## R.sub.1 is H, C.sub.1 -C.sub.8 -alkyl; R.sub.11 is OH, OCH.sub.3, halogen (Cl, Br, I), --SCH.sub.2 CH.sub.2 OH, --SCH.sub.2 CH.sub.2 CH.sub.2 OH, SCH.sub.3 ; R.sub.12 is CH.sub.3, CH.sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 OH, ##STR4## or the pharmaceutically acceptable acid addition salts thereof.

### Claim 2 (depends on 1)

The method, according to claim 1, wherein said inhibiting quantity is from about 1 to about 100 mg/kg.

### Claim 3 (depends on 1)

The method, according to claim 1, wherein said administered compound has the formula ##STR5## wherein R is ##STR6##