# US 4,393,046 A · Combination of thiopeptin and other related sulfur-containing cyclic polypeptide antibiotics with rumen-active diimides to improve ruminant feed efficiency

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- Number: US 4,393,046 A
- Document ID: US4393046A
- Status: Granted
- Kind: A
- Application number: 06/229,806
- Filed: 1981-01-30
- Granted: 1983-07-12
- Earliest claimed: 1981-01-30
- Assignees: Merck & Co., Inc.
- Inventors: Francis P. Baylis; Gary E. Smith
- Web page: https://patentgrep.com/patent/US4393046A

## CPC

- A23K 20/195: Antibiotics
- A23K 20/137: containing two hetero atoms, of which at least one is nitrogen
- A23K: FODDER

## Abstract

Combinations of thiopeptin or one of its analogs with a pyromellitic diimide are shown to synergistically increase the feed efficiency of economically important ruminant animals, especially cattle, sheep, and goats.

## Claims

### Claim 1

An orally administered synergistic combination useful for increasing the feed efficiency of ruminants which comprises a finished feed product and a synergistic combination of from 0.0001% to 0.01% by weight of thiopeptin with from 0.0001% to 0.02% by weight of a pyromellitic diimide compound selected from the group consisting of
(a) pyromellitic diimide;
(b) (N-(2-hydroxyethyl)pyromellitic diimide; and
(c) N,N'-bis-(2-hydroxyethyl)pyromellitic diimide.

### Claim 2 (depends on 1)

The synergistic composition of claim 1 wherein the composition is a finished feed product containing from 0.0005% to 0.002% by weight of the sulfur-containing cyclic polypeptide antibiotic and from 0.0015% to 0.015% by weight of the pyromellitic diimide.

### Claim 3

A method for synergistically increasing the feed efficiency of ruminant animals which comprises orally administering to the ruminant animal, its feed containing an effective amount of a synergistic combination of from 0.0001 to 0.01% by weight of thiopeptin and from 0.0001 to 0.02% by weight of a pyromellitic diimide compound selected from the group consisting of
(a) pyromellitic diimide;
(b) N-(2-hydroxyethyl)pyromellitic diimide; and
(c) N,N'-bis-(2-hydroxyethyl)pyromellitic diimide.

### Claim 4 (depends on 3)

The synergistic method of claim 3 wherein the feed contains from 0.0005% to 0.002% by weight of the thiopeptin and from 0.001% to 0.003% by weight of the substituted pyromellitic diimide.