# US 4,392,997 A · Antigenic peptide compounds

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- Number: US 4,392,997 A
- Document ID: US4392997A
- Status: Granted
- Kind: A
- Application number: 06/389,040
- Filed: 1982-06-16
- Granted: 1983-07-12
- Earliest claimed: 1981-07-06
- Assignees: Northwestern University
- Inventors: Erwin Goldberg
- Web page: https://patentgrep.com/patent/US4392997A

## CPC

- C12N 9/0006: {acting on CH-OH groups as donors (1.1)}
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The novel antigenic peptide compounds of this invention comprise sequences of 12 to 19 amino acids, which include twelve amino acid sequence glutamic acid-glutamine-leucine-isoleucine-glutamine-asparagine-leucine-valine-prol ine-glutamic acid-aspartic acid-lysine, all of the amino acids being in their L-forms. The compounds have utility in vaccines for reducing the fertility of mammals.

## Claims

### Claim 1

The antigenic peptide compounds arranged in a sequence from N-terminal to C-terminal amino acids selected from the class consisting of:
(a) Glu--Gln--Leu--Ile--Gln--Asn--Leu--Val--Pro--Glu--Asp--Lys
(b) Glu--Gln--Leu--Ile--Gln--Asn--Leu--Val--Pro--Glu--Asp--Lys--Leu
(c) Glu--Gln--Leu--Ile--Gln--Asn--Leu--Val--Pro--Glu--Asp--Lys--Leu--Ser
(d) Glu--Gln--Leu--Ile--Gln--Asn--Leu--Val--Pro--Glu--Asp--Lys--Leu--Ser--Arg
(e) Cys--Glu--Gln--Leu--Ile--Gln--Asn--Leu--Val--Pro--Glu--Asp--Lys
(f) Cys--Glu--Gln--Leu--Ile--Gln--Asn--Leu--Val--Pro--Glu--Asp--Lys--Leu
(g) Cys--Glu--Gln--Leu--Ile--Gln--Asn--Leu--Val--Pro--Glu--Asp--Lys--Leu--Ser, and
(h) Cys--Glu--Gln'Leu--Ile--Gln--Asn--Leu--Val--Pro--Glu--Asp--Lys--Leu--Ser-- Arg
wherein Gly represents glycine, and Glu, Gln, Leu, Ile, Asn, Val, Pro, Asp, Lys, Ser, Arg, and Cys, respectively represent the L-amino acid forms of glutamic acid, glutamine, leucine, isoleucine, asparagine, valine, proline, aspartic acid, lysine, serine, arginine, and cysteine.

### Claim 2 (depends on 1)

The peptide compounds (e) to (h) of claim 1.

### Claim 3 (depends on 1)

The peptide compound (e) of claim 1.

### Claim 4 (depends on 1)

The compound (f) to (i) of claim 1.

### Claim 5 (depends on 1)

The peptide compound (g) of claim 1.

### Claim 6 (depends on 1)

The peptide compound (h) of claim 1.