Ureylenebis (hydroxy naphthalenesulfonic acids)
AssigneeAmerican Cyanamid Company
InventorsGerald J. Siuta, Seymour Bernstein
Life of this patent
Estimating the term…
Abstract
Methods of use and compositions of matter of certain ureides of substituted naphthalenesulfonic acids and salts thereof, useful as inhibitors of connective tissue destruction.
Claims15
A method of inhibiting connective tissue destruction in a warm-blooded animal suffering from connective tissue destruction disease which comprises administering to said warm-blooded animal an effective connective tissue destruction inhibiting amount of a compound selected from those of the formula:
- ##STR5## wherein R.sub.1 is selected from the group consisting of hydrogen and --SO.sub.3 A;
- R.sub.2 is selected from the group consisting of hydrogen, ortho-SO.sub.3 A, ortho-methyl and meta-methyl;
- and A is selected from the group consisting of hydrogen and a nontoxic pharmaceutically acceptable cation salt.
A method of inhibiting the degradation sequelae of collagenase activity in a warm-blooded animal suffering from elevated levels of collagenase which comprises administering to said warm-blooded animals an effective collagenase inhibiting amount of a compound selected from those of the formula:
- ##STR6## wherein R.sub.1 is selected from the group consisting of hydrogen and --SO.sub.3 A;
- R.sub.2 is selected from the group consisting of hydrogen, ortho-SO.sub.3 A, ortho-methyl and meta-methyl;
- and A is selected from the group consisting of hydrogen and a nontoxic pharmaceutically acceptable cation salt.
Dependencies are inferred from the claim text.