# US 4,391,809 A · Methods for treating psoriasis

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- Number: US 4,391,809 A
- Document ID: US4391809A
- Status: Granted
- Kind: A
- Application number: 06/206,596
- Filed: 1980-11-13
- Granted: 1983-07-05
- Earliest claimed: 1979-10-15
- Assignees: Warner-Lambert Company
- Inventors: Edward F. Elslager
- Web page: https://patentgrep.com/patent/US4391809A

## CPC

- A61K 31/505: Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Methods for treating psoriasis by administering 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]-quinazoline, 2,4-diamino-5-chloro-6-[(3,4-dichloroanilino)methyl]-quinazoline or a pharmaceutically acceptable acid-addition salt thereof.

## Claims

### Claim 1

A method for treating psoriasis in mammals which comprises administering an antipsoriatic-effective amount of 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline, 2,4-diamino-5-chloro-6-[(3,4-dichloroanilino)methyl]quinazoline or a pharmaceutically acceptable salt thereof, to a mammal in need of said treatment.

### Claim 2 (depends on 1)

The method of claim 1 wherein 0.07 mg to 7.1 mg/kg of weight per day of said compound is administered.

### Claim 3 (depends on 1)

The method of claim 1 wherein said compound is 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline monoacetate.

### Claim 4 (depends on 1)

The method of claim 1 wherein said compound is 2,4-diamino-5-chloro-6-[(3,4-dichloroanilino)methyl]quinazoline monoacetate.

### Claim 5 (depends on 1)

The method defined in claim 1 wherein said mammal is a human.