# US 4,391,747 A · Des asparagine-3-calcitonin

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- Number: US 4,391,747 A
- Document ID: US4391747A
- Status: Granted
- Kind: A
- Application number: 06/348,473
- Filed: 1982-02-12
- Granted: 1983-07-05
- Earliest claimed: 1982-02-12
- Assignees: Armour Pharmaceutical Company
- Inventors: Ronald C. Orlowski; Jay K. Seyler
- Web page: https://patentgrep.com/patent/US4391747A

## CPC

- C07K 14/585: Calcitonins
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.

## Claims

### Claim 1

Des-X.sup.3 -calcitonin, where X is asparagine wherein the calcitonin is salmon, havine, porcine, ovine or eel.

### Claim 2

A peptide having the structure: ##STR27##

### Claim 3

A peptide having the structure: ##STR28##

### Claim 4

A peptide of the structure: ##STR29## where R.sub.1 is S-n-alkyl, Cys or H and R.sub.2 is S-n-alkyl or H, R.sub.1 being S-n-alkyl, Cys or H when R.sub.2 is H and R.sub.2 being S-n-alkyl or H when R.sub.1 is H and H when R.sub.1 is S-n-alkyl or Cys, wherein the S-n-alkyl groups are selected from the group consisting of methylthio, ethylthio, n-propylthio, n-butylthio, and equivalents thereof.

### Claim 5

A peptide of the structure: ##STR30## where R.sub.1 is S-n-alkyl, Cys or H and R.sub.2 is S-n-alkyl or H, R.sub.1 being S-n-alkyl, Cys or H when R.sub.2 is H and R.sub.2 being S-n-alkyl or H when R.sub.1 is H and H when R.sub.1 is S-n-alkyl or Cys, wherein the S-n-alkyl groups are selected from the group consisting of methylthio, ethylthio, n-propylthio, n-butylthio, and equivalents thereof.