16-Hydroxy-5-iodo-prostacyclin analogs of the 1 series

A compound of the formula:

• ##STR72## wherein G is selected from the group --C(O)OR, --CH.sub.2 OH, --C(O)CH.sub.2 OR, --C(O)CH.sub.2 OH, ##STR73## and --C(O)OH wherein R.sub.1 is hydrogen or hydroxy, R is C.sub.1 to C.sub.6 alkyl, or optionally substituted phenyl, wherein the substituents are selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl and R.sub.16 is C.sub.1 to C.sub.6 alkyl;
• C.sub.13 -C.sub.14 is selected from the group --CH.dbd.CH--(trans) and --CH.sub.2 CH.sub.2 --;
• and R.sub.2 is selected from the group ##STR74## wherein R.sub.6 is C.sub.3 to C.sub.5 alkyl;
• R.sub.7 is C.sub.2 to C.sub.4 alkyl;
• R.sub.10 is C.sub.1 to C.sub.4 alkyl;
• R.sub.11 is C.sub.3 to C.sub.7 alkyl;
• R.sub.17 is hydrogen, methyl or ethyl;
• the racemic mixture thereof;
• the mirror image thereof;
• and the pharmaceutically acceptable, non-toxic salts thereof.