Quinone derivatives, their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsShinji Terao, Mitsuru Shiraishi, Kaneyoshi Kato
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Abstract
New quinone derivatives of the formula: ##STR1## wherein R.sup.1 is methyl or methoxy, or two of R.sup.1 combine to represent --CH.dbd.CH--CH.dbd.CH--, R is amino which may be substituted or --OR.sup.4 wherein R.sup.4 is hydrogen, C.sub.1-4 alkyl or --CH.sub.2 --CH.dbd.C(CH.sub.3 --CH.sub.2 --.sub.m H (wherein m is an integer of 1 to 10), and n is an integer of 1 to 10 when R is amino which may be substituted, or n is an integer of 2 to 10 when R is --OR.sup.4, and their hydroquinone forms, have useful physiological activities such as blood-pressure decreasing and antiallergic activities.
Claims8
A compound of the formula:
- ##STR94## wherein n is an integer of 1 to 10, R.sup.1 is methyl or methoxy, or two of R.sup.1 combine to represent --CH.dbd.CH--CH.dbd.CH--, and
- R.sup.2 is a cyclic amino group selected from the class consisting of azetidinyl, pyrrolidinyl, piperazinyl, piperidino and morpholino,
- said cyclic amino groups being unsubstituted or substituted by C.sub.1-4 alkyl, hydroxyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, carboxyl, one of mono- to decaprenyl, benzyl, 3,4,5-trimethoxybenzyl or 3,4-methylenedioxybenzyl,
- or its hydroquinone form,
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition for the treatment of bronchial asthma, allergosis and hypertension which comprises as an active ingredient an effective amount of a compound of the formula:
- ##STR95## wherein n is an integer of 1 to 10, R.sup.1 is methyl or methoxy, or two of R.sup.1 combine to represent --CH.dbd.CH--CH.dbd.CH--, and
- R.sup.2 is a cyclic amino group selected from the class consisting of azetidinyl, pyrrolidinyl, piperazinyl, piperidino and morpholino,
- said cyclic amino groups being unsubstituted or substituted by C.sub.1-4 alkyl, hydroxyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, carboxyl, one of mono- to decaprenyl, benzyl, 3,4,5-trimethoxybenzyl or 3,4-methylenedioxybenzyl,
- or its hydroquinone form,
- or a pharmaceutically acceptable salt thereof,
- in association with a pharmaceutically acceptable carrier or excipient.
A method for the treatment of allergosis in a mammal which comprises administering to said mammal an effective amount of a compound of the formula:
- ##STR96## wherein n is an integer of 1 to 10, R.sup.1 is methyl or methoxy, or two of R.sup.1 combine to represent --CH.dbd.CH--CH.dbd.CH--, and
- R.sup.2 is a cyclic amino group selected from the class consisting of azetidinyl, pyrrolidinyl, piperazinyl, piperidino and morpholino,
- said cyclic amino groups being unsubstituted or substituted by C.sub.1-4 alkyl, hydroxyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, carboxyl, one of mono- to decaprenyl, benzyl, 3,4,5-trimethoxybenzyl or 3,4-methylenedioxybenzyl,
- or its hydroquinone form,
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.