Imino-alkyl and amino-nitrile cyano-guanidines
OwnerPierre J. Baudetinventor
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Abstract
The invention relates to cyanoguanidine derivatives characterized by an imino-alkyl and amino-nitrile structure having the general formula: ##STR1## in which R.sub.1 is a 2-mercapto-ethyl, 2-hydroxy-ethyl, a 2-((4-methyl-5-imidazolyl)thio-methyl)ethyl, or a 2-((4-methyl-5-imidazolyl)dithioformyloxy-methyl)ethyl radical, and R.sub.2 is the methyl radical. The invention relates to the manufacture of imino-methyl and amino-nitrile cyano-guanidines. One compound of invention: N-methyl-N'-cyano-N"-imino-[2-((4-methyl-5-imidazolyl)thio-methyl)ethyl] guanidine is a histamine antagonist in the H.sub.2 receptors and inhibits the secretion of gastric acid. It can be used therapeutically for the treatment of gastric and duodenal ulcers.
Claims1
A cyanoguanidine having the structural formula:
- ##STR13## characterized by the imino-alkyl and amino-nitrile structure wherein R.sub.1 comprises a 2-((4-methyl-5-imidazolyl)thio-methyl)ethyl radical, and R.sub.2 comprises a methyl radical.
Dependencies are inferred from the claim text.