Adenosine deaminase resistant antiviral purine arabinonucleosides
AssigneeRegents of the University of Minnesota
InventorRobert Vince
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Abstract
The preparation of 9-[.alpha.-(2.alpha.,3.beta.-dihydroxy-4.alpha.-(hydroxymethyl) cyclopentyl)]-6-substituted purines: ##STR1## and their derivatives wherein R is amino, mercapto, methylmercapto, hydroxy, halogen, or substituted amino: ##STR2## wherein R' and R" may be the same or different and are hydrogen, methyl, ethyl, propyl or phenyl. The compounds exhibit anti-viral and antitumor activity and are resistant to adenosine deaminase. Acid salts and esters of the purine nucleosides have also been prepared.
Claims5
The adenosine deaminase resistant antiviral purine arabinonucleoside analog 9-[.alpha.-(2.alpha.,3.beta.-dihydroxy-4.alpha.-(hydroxymethyl)cyclopentyl )]-6-substituted purine having the formula:
- ##STR7## and derivatives thereof, wherein R is selected from the group consisting of amino, hydroxyl, mercapto, methylmercapto, halogen and substituted amino:
- ##STR8## wherein R' and R" may be the same or different and are selected from the group consisting of hydrogen, methyl, ethyl, propyl and phenyl.
The adenosine deaminase resistant antiviral purine arabinonucleoside analog 9-[.alpha.-(2.alpha.,3.beta.-dihydroxy-4.alpha.(hydroxymethyl)cyclopentyl) ] adenine having the formula:
- ##STR9## and the acid addition salts thereof.
Dependencies are inferred from the claim text.