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US 4,382,953 AGranted
Ophthalmic solution for intraocular pressure reduction
AssigneeKakenyaku Kako Co., Ltd.
InventorsYukihisa Ishii, Yasuo Sakai, Takao Goto, Kiyoshi Masuda
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AssigneeKakenyaku Kako Co., Ltd.
InventorsYukihisa Ishii, Yasuo Sakai, Takao Goto, Kiyoshi Masuda
Estimating the term…
An ophthalmic solution suitable for adjusting intraocular pressure comprising (A) an ophthalmologically acceptable, water-soluble salt of 2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran, (B) benzalkonium chloride or benzethonium chloride, and (C) a member selected from polyvinyl alcohol, methyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose and hydroxypropylmethyl cellulose, the solution being adjusted to pH 5.0 to 8.0 with a buffer agent. The components (B) and (C) increase greately the intraocular penetration of the component (A) and reduce the irritation to eye of the component (A) so that the pharmacological action of the component (A) can be effectively exhibited. The ophthalmic solution produces an excellent effect on decreasing of intraocular pressure with reduced irritation to eye and stability for a long term.
An ophthalmic solution for the decreasing of intraocular pressure comprising (A) 0.025 to 4.0 w/v % of an ophthalmologically acceptable, water-soluble salt of 2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)bendzofuran, (B) 0.001 to 0.1 w/v % of benzalkonium chloride or benzethonium chloride, and (C) 0.01 to 2.0 w/v % of at least one member selected from the group consisting of polyvinyl alcohol, methyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose and hydroxypropylmethyl cellulose, the solution being adjusted to pH 5.0 to 8.0 with a buffer agent.
Dependencies are inferred from the claim text.