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US 4,382,952 AGranted
Antibiotic roridin L-2 and its use
AssigneeWarner-Lambert Company
InventorsRussell J. Bloem, Richard H. Bunge, James C. French
Life of this patent
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Abstract
The present invention relates to a novel trichothecene antibiotic, roridin L-2, and a process for the production and the method of using said compound.
Claims3
Antibiotic roridin L-2 having the structural formula ##STR3## and characterized by:
- (a) an infrared spectrum in potassium bromide having principal absorptions at 3450, 2970, 1782, 1750, 1640, 1600, 1435, 1284, 1180, 1084, 1030 and 965 reciprocal centimeters
- (b) [.alpha]sub.D 23=+83.6.degree. (1.0% in chloroform)
- (c) a proton magnetic resonance spectrum in CDCl.sub.3 having principal signals at (s=singlet, d=doublet, t=triplet, m=multiple) 0.83s, 1.15d (J=6), 1.72s, 2.02m, 2.81d (J=4), 3.13d (J=4), 3.5-4.0 (complex signals;
- area=3), 4.80d (J=2), 5.49 broad d (J=6), 5.22-6.02 (complex signals;
- area=3), 6.08dd (J=4,6) 6.06t (J=11);
- and 7.60dd (J=11,15) parts per million downfield from tetramethylsilane
- (d) a carbon 13 nuclear magnetic resonance spectrum in CDCl.sub.3 having principal signals in parts per million, at:
- ______________________________________ Ppm (downfield Ppm (downfield from TMS) from TMS) ______________________________________ 173.95 73.46 167.43 69.74 166.46 66.83 143.37 66.34 140.57 65.59 138.89 62.51 130.53 48.86 118.88 48.00 118.72 44.28 116.67 36.19 85.38 29.23 78.91 28.04 78.42 23.19 77.02 CDCl.sub.3 21.14 75.62 18.44 75.40 6.57 ______________________________________
5 more elements
Dependencies are inferred from the claim text.