2-(Amino acid-thio)-1-carbapen-2-em-3-carboxylic acids and congeners
AssigneeSchering Corporation
InventorAdriano Afonso
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Abstract
2-(Amino acid-thio)-1-carbapen-2-em-3-carboxylic acids and congeners having useful antibacterial activity are disclosed. The compounds are prepared in a reaction sequence starting with a 4-allylazetidinone.
Claims3
(5R,6S,8R,2'S)-2 -[(2'-amino-2'-carboxyethyl)thio]-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carb oxylic acid, sodium salt.
A pharmaceutical composition comprising an antibacterially effective amount of (5R,6S,8R,2'S)-2-[2'-amino-2'-carboxyethyl)thio]-6-(1-hydroxyethyl)-1-carb apen-2-em-3-carboxylic acid, sodium salt together with a non-toxic pharmaceutically acceptable carrier.
A method of eliciting an antibacterial response in a warm-blooded animal to a susceptible bacterial infection which comprises administering to said animal a non-toxic antibacterially effective amount of (5R,6S,8R,2'S)-2-[2'-amino-2'-carboxyethyl)thio]-6-(1-hydroxyethyl)-1-carb apen-2-em-3-carboxylic acid, sodium salt, together with a non-toxic pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.