Anti-allergic aryl ether derivatives
AssigneeBoehringer Mannheim GmbH
InventorsWerner Winter, Walter-Gunar Friebe, Androniki Roesch, Otto-Henning Wilhelms
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Abstract
An aryl ether derivative of the formula ##STR1## in which A is an oxygen atom or an >N--R.sub.1 grouping, R.sub.1 is a hydrogen atom or a lower alkyl radical, B is an alkylene radical containing 2 to 4 carbon atoms, R.sub.2 and R.sub.3 each independently is a hydrogen or halogen atom, hydroxyl group or lower alkyl, lower alkoxy or lower alkanoyl radical, R.sub.4 is a hydrogen atom or an acyl radical, and n is an integer from 1 to 5, or a pharmacologically acceptable salt thereof, which possesses anti-allergic activity.
Claims10
An aryl ether derivative of the formula ##STR5## in which A is an oxygen atom or an >N--R.sub.1 grouping,
- R.sub.1 is a hydrogen atom or a lower alkyl radical,
- B is an alkylene radical containing 2 to 4 carbon atoms,
- R.sub.2 and R.sub.3 each independently is a hydrogen or halogen atom, hydroxyl group or lower alkyl, lower alkoxy or lower alkanoyl radical,
- R.sub.4 is a hydrogen atom;
- a C.sub.1-4 -alkanoyl radical optionally substituted by halogen, phenyl or naphthyl;
- a C.sub.1-4 -alkenoyl radical optionally substituted by phenyl or naphthyl;
- a benzoyl, furancarbonyl, thiophen carbonyl or pyridinecarbonyl radical optionally substituted by halogen, hydroxyl, lower alkyl, lower alkoxy, lower alkoxycarbonyl, lower alkanoyloxy, carboxyl, nitro, amino, lower alkanoylamino, nitrile, trifluoromethyl, carbamoyl, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, lower alkanoyl, benzoyl, hydroxy lower alkyl or lower alkoxy lower alkyl;
- a C.sub.3 -C.sub.7 -cycloalkylcarbonyl or carbamoyl radical optionally substituted by lower alkyl, phenyl or naphthyl;
- a C.sub.1-4 -alkanesulphonic acid radical;
- or a phenyl- or naphthyl-sulphonic acid radical, and
- n is an integer from 1 to 5,
- or a pharmacologically acceptable salt thereof.
Dependencies are inferred from the claim text.