3-[2-(Mono-and dialkylamino)propyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-C]pyridin- 5-ones useful for treating bronchospastic diseases
AssigneeWarner-Lambert Company
InventorsDavid T. Connor, Charles F. Schwender, Roderick J. Sorenson, Paul C. Unangst
Life of this patent
Estimating the term…
Abstract
Anticholinergic 3-[2-(mono- and dialkylamino)-propyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]-pyridin- 5-ones useful for treating bronchospastic diseases in mammals are disclosed. Also disclosed are methods for preparing said compounds, pharmaceutical compositions containing them and methods for using said pharmaceutical compositions. A method for preparing the intermediate which is required to prepare the unsubstituted benzopyrano-[3,4-c]pyridin-5-ones of the invention is also disclosed.
Claims15
A compound having the structural formula I ##STR12## wherein R.sub.1 is H, alkyl of from 1 to 6 carbon atoms, alkoxy of from 1 to 6 carbon atoms, halo, or acetylamino;
- R.sub.2 is H, alkyl of from 1 to 6 carbon atoms, or alkoxy of from 1 to 6 carbon atoms;
- R.sub.3 is H, or alkoxy of from 1 to 6 carbon atoms;
- R.sub.1 and R.sub.2 taken together are OCH.sub.2 O;
- R.sub.2 and R.sub.3 taken together are CH.dbd.CH--CH.dbd.CH;
- X is CH.sub.3, C.sub.2 H.sub.5, n-C.sub.3 H.sub.7, or n-C.sub.4 H.sub.9 ;
- Y is H, CH.sub.3, C.sub.2 H.sub.5 n-C.sub.3 H.sub.7, n-C.sub.4 H.sub.9, or s-C.sub.4 H.sub.9 ;
- and the pharmaceutically acceptable salts thereof, provided that R.sub.1 and R.sub.2 are not both OCH.sub.3 when Y is H.
Dependencies are inferred from the claim text.