Naphthyridine derivatives and their use as anti-bacterials
AssigneesDainippon Pharmaceutical Co., Ltd., Laboratoire Roger Bellon
InventorsJun-ichi Matsumoto, Shinichi Nakamura
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Abstract
A 1,8-naphthyridine compound of the formula ##STR1## wherein R is a vinyl or 2-fluoroethyl group, and R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms, and the esters thereof and salts thereof. For example, 7-(3-amino-1-pyrrolidinyl)-6-fluoro-1,4-dihydro-4-oxo-1-vinyl-1,8-naphthyr idine-3-carboxylic acid and nontoxic salts thereof, which are covered by the aforesaid compound, are useful as an antibacterial agent.
Claims4
A 1,8-naphthyridine compound of the formula ##STR9## wherein R is vinyl or 2-fluoroethyl,
- R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or lower alkyl having 1 to 4 carbon atoms, and
- R.sub.3 ' is a hydrogen atom, lower alkyl having 1 to 6 carbon atoms, pivaloyloxymethyl, ethoxycarbonyloxyethyl, 5-indanyl or phthalidyl
- or a non-toxic salt thereof.
7-(3-amino-1-pyrrolidinyl )-6-fluoro-1,4-dihydro-4-oxo-1-vinyl-1,8-naphthyridine-3-carboxylic acid or a non-toxic salt thereof.
A method for the treatment of a bacterial infectious disease which comprises administering to a warm-blooded animal suffering from such disease an antibacterially effective amount of a 1,8-naphthyridine compound of the formula ##STR10## or a non-toxic salt thereof.
Dependencies are inferred from the claim text.