Reduced naphthalenes, their preparation and use
AssigneeBeecham Group Limited
InventorsAlexander C. Goudie, Josephine M. Cox
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AssigneeBeecham Group Limited
InventorsAlexander C. Goudie, Josephine M. Cox
Estimating the term…
A compound of the formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: Ar is phenyl, optionally substituted by one or more C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, cyano, nitro, hydroxy, CONH.sub.2, CO.sub.2 W wherein W is C.sub.1-6 alkyl or C.sub.1-4 alkylphenyl which phenyl may be substituted by one or more C.sub.1-4 alkyl, C.sub.1-4 alkoxy or halogen, NR.sub.1 R.sub.2 wherein R.sub.1 and R.sub.2 are selected from hydrogen or C.sub.1-6 alkyl, NHCO C.sub.1-6 alkyl or C.sub.1-6 alkylcarbonyloxy; phenyl disubstituted on adjacent carbon atoms by methylenedioxy; furyl or thienyl; the dotted lines represent an optionally present double bond; and X is CO or CR.sub.1 OH wherein R.sub.1 is hydrogen or C.sub.1-4 alkyl, having useful pharmacological activity, processes for their preparation and their use.
A compound of formula (I):
2-(4-Dimethylaminoben zylidene)-3,4,8,8a-tetrahydro-8a-methyl-1,6(2H,7H)-naphthalenedione, or 2-(3-hydroxybenzylidene)-3,4,8,8a-tetrahydro-8a-methyl-1,6(2H,7H)-napthale nedione.
Dependencies are inferred from the claim text.