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US 4,382,093 AGranted
9-Aminoalkylfluorenes
AssigneeEli Lilly and Company
InventorsWilliam B. Lacefield, Richard L. Simon
Life of this patent
Estimating the term…
Abstract
Fluorenes bearing a 9-aminoalkyl substituent are useful antiarrhythmic agents. Pharmaceutical formulations containing such compounds are provided, as well as a method of treatment.
Claims15
A pharmaceutical formulation useful in the treatment of cardiac arrhythmias which comprises a carrier or diluent admixed with an antiarrhythmic amount of a 9-aminoalkylfluorene antiarrhythmic agent of the formula ##STR12## wherein:
- R.sup.o is hydroxy, cyano, CONR.sup.4 R.sup.5 or COOR.sup.9 in which R.sup.4 and R.sup.5 independently are hydrogen or C.sub.1 -C.sub.6 alkyl and R.sup.9 is hydrogen or C.sub.1 -C.sub.4 alkyl;
- R.sup.2 and R.sup.3 independently are hydrogen, C.sub.1 -C.sub.6 alkyl, CH.sub.2 C.sub.2 -C.sub.5 alkenyl, phenyl-C.sub.1 -C.sub.3 alkyl;
- or taken together with the nitrogen to which they are attached are a cyclic group of the formula ##STR13## in which R.sup.8 is hydrogen or C.sub.1 -C.sub.4 alkyl;
- A is CH.sub.2, O or NH;
- and y is zero or one;
- provided that R.sup.2 is hydrogen when R.sup.1 is hydroxy;
- n is 3, 4 or 5;
- R.sup.6 and R.sup.7 independently are hydrogen, C.sub.1 -C.sub.4 alkyl or halogen;
- and the pharmaceutically acceptable salts thereof.
6 more elements
Dependencies are inferred from the claim text.