Therapeutic method for treating blood-clotting defects with factor VIIa
AssigneeBaxter Travenol Laboratories, Inc.
InventorWilliam R. Thomas
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Abstract
Patients having a clotting factor defect can be successfully treated by the administration of a composition containing effective hemostatic amounts of factor VIIa. Preferably, the factor VIIa is substantially free of factors IXa and Xa. Procedures for preparing the above therapeutic compositions are also described.
Claims19
A method for treating a patient having a clotting factor defect, comprising administering to the patient an effective hemostatic amount of factor VIIa, which factor VIIa is uncontaminated by other activated blood clotting factors having sufficient activity alone to produce a hemostatic effect.
The method of claim 13 wherein the stabilizer is a protein at a concentration of greater than about 1 mg/ml.
The method of claim 14 wherein the protein is albumin.
A method for treating a patient having a clotting factor deficiency or inhibitor, comprising administering to the patient an effective hemostatic amount of a composition consisting essentially of factor VIIa, and wherein the factor VIIa is uncontaminated by other activated blood clotting factors having sufficient activity to produce a hemostatic effect.
In a method for treating a patient having a clotting factor deficiency or inhibitor wherein an activated prothrombin complex containing factors VIIa, IXa and Xa is administered to the patient, the improvement comprising administering factor VIIa to the patient substantially free of factors IXa and Xa.
Dependencies are inferred from the claim text.