US 4,382,031 AGranted

Intermediates for the preparation of biotin

AssigneeHoffmann-La Roche Inc.

InventorsEnrico G. Baggiolini, Hsi L. Lee, Milan R. Uskokovic

Life of this patent

Estimating the term…

A process is disclosed for producing d-biotin from L or DL-cystine ester via novel intermediates.

Dependent claims

An optically active compound of the formula:

##STR14## wherein R.sub.3 is --COOR.sub.1, --CHO or ##STR15## R.sub.1 is lower alkyl, aryl or aryl (lower) alkyl and R.sub.2 is aryl (lower) alkyl, in which the aryl moiety in the above substituents is phenyl, naphthyl, anthryl, phenanthryl or azulyl which can be unsubstituted or substituted in one or more positions with halogen, nitro, lower alkenedioxy, lower alkyl or lower alkoxy, or its racemate.

Dependencies are inferred from the claim text.

C07D 495/04
In which the condensed system contains two hetero rings: ortho-condensed systems
C07D 281/00
Heterocyclic compounds containing rings of more than six members having one nitrogen
C07D 513/08
In which the condensed system contains two hetero rings: bridged systems
C07D
Heterocyclic compounds

From the US filing history. Foreign family members aren’t listed.

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