Separation of plasma proteins from cell culture systems
AssigneeMonsanto Company
InventorG. Edward Paget
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Abstract
Plasma proteins are separated from cell culture systems such as, for example, fermentation broths of microbial cell cultures and expended media of mammalian cell cultures, by adsorption with water-insoluble, cross-linked polyelectrolyte copolymers.
Claims19
A process of separating a plasma protein component from its admixture in a cell culture system comprising adsorbing said plasma protein component therefrom by contact with a water-insoluble, cross-linked polyelectrolyte copolymer of olefinically unsaturated monomer having from 2 to about 4 carbon atoms and .alpha.,.beta.-unsaturated polycarboxylic acid or anhydride having from 4 to about 6 carbon atoms and containing pendant diloweralkylaminoloweralkylimide functional groups.
The process of claim 13 in which the mammalian cells are human liver cells.
Dependencies are inferred from the claim text.