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US 4,381,772 AGranted
Bioerodible diaphragm
OwnerFernando G. Guistini, Frank J. Keefer +1inventors
InventorsFernando G. Guistini, Frank J. Keefer, Robert F. Keefer
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OwnerFernando G. Guistini, Frank J. Keefer +1inventors
InventorsFernando G. Guistini, Frank J. Keefer, Robert F. Keefer
Estimating the term…
An improved contraceptive diaphragm is provided which has a bioerodible matrix that disintegrates in the vaginal fluids within a predetermined period of time. The matrix is made from a water soluble gel, more particularly from a water soluble polymeric resin gel, and preferably from a polyvinyl alcohol resin gel. The solubility of the water soluble gel in the vaginal fluids is controllably reduced for example, by heat treatment of the gel after formation of the diaphragm. The diaphragm does not have to be removed in a single piece, but is excreted as a slight vaginal discharge. In one aspect of the invention, a natural collagenous protein is embedded in the matrix to assure sealing adherence of the diaphragm when positioned in the vagina. In another aspect of the invention a hydrophilic material is provided at the center of the matrix to effectively absorb secreted cervical mucus thereby creating a dry passageway which will impede entrance of the sperm.
A contraceptive vaginal diaphragm composed of a bioerodible matrix which disintegrates in the vaginal fluids within a selected predetermined period of time between 30 minutes to 30 hours, said matrix being made from a water soluble gel.
A contraceptive vaginal diaphragm composed of a bioerodible matrix which disintegrates in the vaginal fluids within a selected predetermined period of time between 30 minutes to 30 hours, said matrix being made from a heat treated water soluble gel.
A contraceptive vaginal diaphragm composed of a bioerodible matrix which disintegrates in the vaginal fluids within a selected predetermined period of time between 30 minutes to 30 hours, said matrix being made from a water soluble polymeric resin gel.
A contraceptive vaginal diaphragm composed of a bioerodible matrix which disintegrates in the vaginal fluids within a selected predetermined period of time between 30 minutes to 30 hours, said matrix being made from a water soluble polyvinyl alcohol resin gel.
A contraceptive vaginal diaphragm composed of a bioerodible matrix which disintegrates in the vaginal fluids within a selected predetermined period of time between 30 minutes to 30 hours, said matrix consisting essentially of a heat treated water soluble polyvinyl alcohol resin gel, a plasticizer, and peripherally embedded collagenous particles.
A contraceptive vaginal diaphragm composed of a bioerodible matrix which disintegrates in the vaginal fluids within a selected predetermined period of time between 30 minutes to 30 hours, said matrix consisting essentially of a heat treated water soluble polyvinyl alcohol resin gel, a plasticizer, peripherally embedded collagenous particles, centrally embedded hydrophilic crystals and a spermatocide.
Dependencies are inferred from the claim text.