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US 4,381,395 AGranted
Process for preparing an imidazole derivative
AssigneeSK&F Lab Co.
InventorsTsutomu Teraji, Yoshiharu Nakai, Graham J. Durant
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Abstract
This invention relates to new processes for preparing an imidazole derivative, i.e. cimetidine, by (1) reacting an imidazolylmethylthioethylamine with an amidine or (2) reacting a N-cyano-N'-imidazolylmethylthioethyl formamidine with methylamine or (3) reacting a N-methyl-N'-imidazolylmethylthioethyl formamidine with cyanamide.
Claims2
A process for preparing an imidazole derivative of the formula:
- ##STR3## which comprises (1) reacting a compound of the formula:
- ##STR4## with a compound of the formula:
- ##STR5## wherein X.sup.1 is an aromatic 5-membered N-containing heterocycle-N-yl or a group of the formula:
- --S(O).sub.n --Z in which Z is hydroxy or alkyl, and n is 1 or 2, provided that X.sup.1 is not a pyrazolyl ring;
- or
- (2) reacting a compound of the formula:
- ##STR6## wherein X.sup.2 is cyanamide, an aromatic 5-membered N-containing heterocycle-N-yl or a group of the formula:
- --S(O).sub.n --Z in which Z is hydroxy or alkyl, and n is 1 or 2, provided that X.sup.2 is not a pyrazolyl ring, with methylamine;
- or
- (3) reacting a compound of the formula:
- ##STR7## wherein X.sup.3 is a group of the formula:
- --S(O).sub.n --Z in which Z is hydroxy or alkyl, and n is 1 or 2,
- with cyanamide or a salt thereof.
10 more elements
Dependencies are inferred from the claim text.