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US 4,381,311 AGranted
Antiinflammatory 4,5-diaryl-.alpha.-(polyhalomethyl)-2-thiophenemethanols
AssigneeE. I. Du Pont de Nemours and Company
InventorStephen B. Haber
Life of this patent
Estimating the term…
Abstract
4,5-Diaryl-.alpha.-(polyhalomethyl)-2-thiophenemethanols such as 4-(4-methoxyphenyl)-5-(4-methylthiophenyl)-.alpha.,.alpha.-bis(trifluorome thyl)-2-thiophenemethanol useful for treating arthritis and/or alleviating pain.
Claims48
A compound of the formula:
- ##STR14## where R.sub.1 and R.sub.2 independently=CF.sub.3, CF.sub.2 H, CFCl.sub.2, CF.sub.2 Cl, CClFH, CCl.sub.2 H, CH.sub.2 F, CF.sub.3 CF.sub.2 or C.sub.1 -C.sub.2 alkyl with the provisos (1) that no more than one of R.sub.1 and R.sub.2 can be selected from the group consisting of CH.sub.2 F and C.sub.1 -C.sub.2 alkyl and (2) that no more than one of R.sub.1 and R.sub.2 can be CF.sub.3 CF.sub.2 ;
- R.sub.3 and R.sub.4 independently=pyridyl or ##STR15## where X=H, F, Cl, Br, NO.sub.2, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, di(C.sub.1 -C.sub.2 alkyl) amino or C.sub.1 -C.sub.2 alkyl S(O).sub.n ;
- where n=0, 1 or 2;
- Y=H, F or Cl with the proviso that when Y is F or Cl, then X is F or Cl;
- R.sub.5 =H, C.sub.1 -C.sub.4 alkyl, (C.sub.1 -C.sub.3 alkyl)C(O) or CO.sub.2 R.sub.7 ;
- R.sub.6 =H or C.sub.1 -C.sub.2 alkyl;
- and
- R.sub.7 =C.sub.1 -C.sub.4 alkyl.
5 more elements
Dependencies are inferred from the claim text.