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US 4,381,305 AGranted
Ethylenediamine derivatives and pharmaceutical compositions containing same
AssigneeSimes S.p.A.
InventorsCesare Casagrande, Giorgio Ferrari
Life of this patent
Estimating the term…
Abstract
New derivatives of 1,2-ethylenediamine and salts thereof endowed with vascular antispasmodic and antiallergic activity; processes for preparing them, some new intermediates useful in their preparation and pharmaceutical compositions containing them.
Claims5
A compound of formula ##STR9## wherein R.sub.1 is a hydrogen atom, a lower alkyl, or an arylalkyl radical;
- R.sub.2 is a lower alkyl radical;
- Ar.sub.1 is an aryl radical which may be substituted by one or more radicals selected from the group consisting of nitro, chlorine and methoxy, an arylalkyl radical, or a heterocyclic radical selected from the group consisting of furanyl, thienyl and pyridinyl;
- Ar.sub.2 and Ar.sub.3 are the same or different aryl radicals which may be substituted by one or more radicals selected from the group consisting of chlorine, fluorine, methyl and methoxy;
- A.sub.1 is an oxygen atom or 2 hydrogen atoms;
- A.sub.2 is hydrogen;
- A.sub.3 is a hydrogen atom, a hydroxyl radical, or, together with A.sub.2, is a bond of a double bond.
3 more elements
A pharmaceutical composition comprising a vascular antispasmodic or antiallergic amount of a compound of formula ##STR10## wherein R.sub.1 is a hydrogen atom, a lower alkyl, or an arylalkyl radical;
- R.sub.2 is a lower alkyl radical;
- Ar.sub.1 is an aryl radical which may be substituted by one or more radicals selected from the group consisting of nitro, chlorine and methoxy, an arylalkyl radical, or a heterocyclic radical selected from the group consisting of furanyl, thienyl and pyridinyl;
- Ar.sub.2 and Ar.sub.3 are the same or different aryl radicals which may be substituted by one or more radicals selected from the group consisting of chlorine, fluorine, methyl and methoxy;
- A.sub.1 is an oxygen atom or 2 hydrogen atoms;
- A.sub.2 is hydrogen;
- A.sub.3 is a hydrogen atom, a hydroxyl radical, or, together with A.sub.2, is a bond of a double bond,
- or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable excipient.
4 more elements
Dependencies are inferred from the claim text.