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US 4,381,304 AGranted
4,9-Dihydro-4,9-dioxo-1H-cyclohepta[b]pyridine derivatives
AssigneeAyerst McKenna and Harrison Ltd.
InventorsBozidar Palameta, Tibor Bogri, Jehan Bagli
Life of this patent
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Abstract
Aldose reductase inhibitors of the formula ##STR1## in which R.sup.1 is COOH and R.sup.2 is hydrogen, 8-halo or 6-hydroxy, or R.sup.1 is CON(R.sup.3)-CH.sub.2 COOH wherein R.sup.3 is lower alkyl and R.sup.2 is hydrogen or 8-halo are useful for treating diabetic complications.
Claims9
A compound of formula I ##STR5## in which R.sup.1 is COOH and R.sup.2 is hydrogen, 8-halo or 6-hydroxy;
- or R.sup.1 is CON(R.sup.3)--CH.sub.2 COOH wherein R.sup.3 is lower alkyl and R.sup.2 is hydrogen or 8-halo;
- or a therapeutically acceptable salt thereof with an organic or inorganic base.
Dependencies are inferred from the claim text.