Sulphur analogs of cephalosporins having a nucleophile substituted in the 7 position

An antibacterial pharmaceutical composition, comprising a material selected from the group consisting of

• (1) a cephalosporanic compound having the structural formula:
• ##STR13## wherein R, R.sup.1 and X are the same as defined above, and R.sup.2 is selected from the group consisting of hydrogen, halogen, and hydroxyl, alkoxyl, acyloxyl, alkylamino, arylamino, carboxyl, carbonyl, sulfonyl, carbamyl, thiocarbonyl, carbonyloxyl, methyl and methylacetoxy groups;
• and
• (2) pharmaceutically acceptable salts of said cephalosporanic compounds;
• and a pharmaceutically acceptable carrier therefor.

A process for preparing an antibacterial pharmaceutical composition, comprising mixing a material selected from the group consisting of

• (1) a cephalosporanic compound having the structural formula:
• ##STR14## wherein R, R.sup.1 and X are the same as defined above, and R.sup.2 is selected from the group consisting of hydrogen, halogen, and hydroxyl, alkoxyl, acyloxyl, alkylamino, arylamino, carboxyl, carbonyl, sulfonyl, carbamyl, thiocarbonyl, carbonyloxyl, methyl and methylacetoxy groups;
• and
• (2) pharmaceutically acceptable salts of said cephalosporanic compounds with a pharmaceutically acceptable carrier therefor.