Substituted carbonyl phosphinyl-alkanoyl compounds

A compound of the formula ##STR266## wherein X is an imino acid of the formula ##STR267## R.sub.7 is hydrogen, lower alkyl, halogen, keto, hydroxy, ##STR268## azido, amino, ##STR269## a 1- or 2-naphthyl of the formula ##STR270## --(CH.sub.2).sub.m -cycloalkyl, ##STR271## --O--lower alkyl, ##STR272## a 1- or 2-naphthyloxy of the formula ##STR273## --S--lower alkyl, ##STR274## or a 1- or 2-naphthylthio of the formula ##STR275## R.sub.8 is keto, halogen, ##STR276## ##STR277## --O--lower alkyl, a 1- or 2-naphthyloxy of the formula ##STR278## --S--lower alkyl, ##STR279## or a 1- or 2-naphthylthio of the formula ##STR280## R.sub.9 is keto or ##STR281## R.sub.10 is halogen or --Y--R.sub.16 ;

• R.sub.11, R.sub.11 ', R.sub.12 and R.sub.12 ' are independently selected from hydrogen and lower alkyl or R.sub.11 ', R.sub.12 and R.sub.12 ' are hydrogen and R.sub.11 is ##STR282## R.sub.13 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, hydroxy, phenyl, phenoxy, phenylthio, or phenylmethyl;
• R.sub.14 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, or hydroxy;
• m is zero, one, two or three;
• p is one, two or three provided that p is more than one only if R.sub.13 or R.sub.14 is hydrogen, methyl, methoxy, chloro, or fluoro;
• R.sub.15 is hydrogen or lower alkyl of 1 to 4 carbons;
• Y is oxygen or sulfur;
• R.sub.16 is lower alkyl of 1 to 4 carbons, ##STR283## or the R.sub.16 groups join to complete an unsubstituted 5- or 6-membered ring or said ring in which one or more of the carbons has a lower alkyl of 1 to 4 carbons or a di(lower alkyl of 1 to 4 carbons) substituent;
• n is zero or one;
• R.sub.5 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl or phenethyl;
• R.sub.3 and R.sub.6 are independently selected from hydrogen, lower alkyl, benzyl, benzhydryl, or ##STR284## wherein R.sub.17 is hydrogen, lower alkyl, or phenyl, and R.sub.18 is hydrogen, lower alkyl, lower alkoxy, phenyl, or R.sub.17 and R.sub.18 taken together are ##STR285## R.sub.4 is hydrogen, lower alkyl, halo substituted lower alkyl, ##STR286## wherein R.sub.13 and p are as defined above and q is zero or an integer from 1 to 7, cycloalkyl, ##STR287## R.sub.19 is lower alkyl, benzyl or phenethyl;
• R.sub.20 is hydrogen, lower alkyl, benzyl or phenethyl;
• R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, lower alkyl, halo substituted lower alkyl, ##STR288## wherein q, R.sub.13, p and m are as defined above;
• and when either or both of R.sub.3 and R.sub.6 are hydrogen a basic addition salt or an amino acid addition salt thereof.