Chemical compounds

A compound of the formula ##STR60## wherein p is 1 or 2;

• R.sup.7 is a leaving group selected from halogen, (lower)alkoxy, (lower)alkylthio, phenoxy, phenylthio, substituted phenoxy and substituted phenylthio wherein the phenyl ring may contain 1 or 2 substituents selected from halogen, (lower)alkyl, (lower)alkoxy and nitro;
• and
• R.sup.12 is A(CH.sub.2).sub.m Z(CH.sub.2).sub.n NH--, R.sup.2 R.sup.3 N-- or HS(CH.sub.2).sub.n NH--;
• in which R.sup.2 and R.sup.3 each are independently hydrogen, (lower)alkyl, (lower)alkenyl, (lower)alkynyl, cyclo(lower)alkyl(lower)alkyl, hydroxy(lower)alkyl, (lower)alkoxy(lower)alkyl, (lower)alkylthio(lower)alkyl, 2-fluoroethyl, 2,2,2-trifluoroethyl or cyano(lower)alkyl, or, when R.sup.2 is hydrogen, R.sup.3 may also be cyclo(lower)alkyl, amino(lower)alkyl, (lower)alkylamino(lower)alkyl, di(lower)alkylamino(lower)alkyl, pyrrolidino(lower)alkyl, piperidino(lower)alkyl, piperazino(lower)alkyl, substituted pyridyl(lower)alkyl wherein the pyridyl ring may contain one substituent selected from (lower)alkyl, (lower)alkoxy, hydroxy, amino and halogen, amino, (lower)alkylamino, di(lower)alkylamino, hydroxy, (lower)alkoxy, 2,3-dihydroxypropyl, cyano, amidino, (lower)alkylamidino, phenyl, phenyl(lower)alkyl, substituted phenyl or substituted phenyl(lower)alkyl, wherein the phenyl ring may contain one or two substituents independently selected from (lower)alkyl, hydroxy, (lower)alkoxy and halogen or one substituent selected from methylenedioxy, trifluoromethyl and di(lower)alkylamino;
• or R.sup.2 and R.sup.3, taken together, may be --CH.sub.2 CH.sub.2 X(CH.sub.2).sub.r --;
• r is an integer of from 1 to 3, inclusive;
• X is methylene, sulfur, oxygen or N--R.sup.4, provided that, when p is 2 and R.sup.7 is methoxy, R.sup.2 and R.sup.3 taken together with the nitrogen to which they are attached, may not be morpholino, and that, when r is 1, X is methylene;
• R.sup.4 is hydrogen, (lower)alkyl, (lower)alkenyl, (lower)alkynyl, (lower)alkanoyl or benzoyl;
• m is an integer of from zero to 2, inclusive;
• n is an integer of from 2 to 4, inclusive;
• Z is sulfur, oxygen or methylene;
• A is phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl;
• provided that A may contain one or two substituents, the first substituent being selected from (lower)alkyl, hydroxy, trifluoromethyl, halogen, amino, hydroxymethyl, (lower)alkoxy, ##STR61## and the second substituent being selected from (lower)alkyl, hydroxy, trifluoromethyl, halogen, amino, hydroxymethyl and (lower)alkoxy;
• q is an integer of from 0 to 6, inclusive;
• R.sup.14 and R.sup.15 independently are hydrogen or (lower)alkyl, or if R.sup.14 is hydrogen, R.sup.15 also may be (lower)alkanoyl or benzoyl, or R.sup.14 and R.sup.15, taken together, may be ethylene;
• and
• R.sup.5 and R.sup.6 each are independently hydrogen, (lower)alkyl, (lower)alkenyl, (lower)alkynyl, (lower)alkoxy(lower)alkyl, cyclo(lower)alkyl or phenyl, provided that R.sup.5 and R.sup.6 may not both be cyclo(lower)alkyl or phenyl;
• or R.sup.5 and R.sup.6, taken together with the nitrogen atom to which they are attached, may be pyrrolidino, methylpyrrolidino, dimethylpyrrolidino, piperidino, methylpiperidino, dimethylpiperidino, hydroxypiperidino, homopiperidino, heptamethyleneimino or octamethyleneimino;
• or a salt, hydrate, solvate or N-oxide thereof.