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US 4,380,625 AGranted
Process for the preparation of purified aminoglycoside antibiotics
AssigneeBayer Aktiengesellschaft
InventorsPeter Stadler, Wolfgang Koebernick, Samir Samaan, Wolfgang Gau
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Abstract
The invention relates to an improved process for the isolation and purification of aminoglycoside antibiotics of Formula (I) as defined herein combining selective lipophilization of the compound of Formula (I) in the crude product obtained by fermentation with controlled liquid/liquid extraction.
Claims16
A process for the preparation of a pure aminoglycoside antibiotic, which comprises acylating or arylsulphenylating
- (a) a pre-purified compound of the formula ##STR10## wherein X denotes a radical of the formulae ##STR11## Y denotes a radical of the formulae ##STR12## R denotes a hydrogen atom or an ethyl group, R.sub.1 denotes a C.sub.1 to C.sub.6 alkyl group, and one of the radicals Z or W denotes hydrogen and the other radical Z or W denotes hydrogen or hydroxyl,
- to give a compound of the formula ##STR13## wherein X' represents a radical of the formulae ##STR14## Y' represents a radical of the formulae ##STR15## the radicals R.sub.2 are identical or different and represent a hydrogen atom or an acyl or arylsulphenyl protective group, with the proviso that at most two of the radicals R.sub.2 represent hydrogen atoms, and
- R, R.sub.1, Z and W have the abovementioned meaning,
- (b) subjecting the compound of the formula (II) from step (a) to liquid/liquid extraction in a two-phase aqueous/organic solvent system and isolating said compound of the Formula (II) from the extracts, and
- (c) then splitting off the protective group(s).
2 more elements
Dependencies are inferred from the claim text.