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US 4,380,543 AGranted
Antimicrobial 8-cyano-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxyl ic acids
AssigneeRiker Laboratories, Inc.
InventorRichard M. Stern
Life of this patent
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Abstract
The compounds 8-cyano-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid and 8-cyano-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-c arboxylic acid are disclosed as potent antimicrobial agents. Pharmaceutically-acceptable carboxylate salts, esters, acyl chlorides, amides and alkylaminoalkyl ester salts of the acids are also disclosed.
Claims5
A compound of the formula:
- ##STR3## wherein X is hydrogen or fluorine, or a pharmaceutically acceptable carboxylate salt thereof, an alkyl or alkylaminoalkyl ester thereof where the alkyl group contains 1 to 4 carbon atoms, an alkylaminoalkyl ester salt thereof where the alkyl group contains 1 to 4 carbon atoms, an acyl chloride thereof, or an amide thereof having the formula --NR.sub.1 R.sub.2 where R.sub.1 and R.sub.2 are independently hydrogen or an alkyl group containing 1 to 4 carbon atoms.
Dependencies are inferred from the claim text.