Cephalosporin derivatives
AssigneeTakeda Chemical Industries, Ltd.
InventorsMichihiko Ochiai, Akira Morimoto
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Abstract
Novel 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporanic acid derivatives of the formula: ##STR1## wherein R.sup.1 NH is an amino group which may optionally be protected, R.sup.2 is a halogen atom or a hydroxyl, thiol or amino group which may optionally be substituted; COOR is a carboxyl group which may optionally be esterified, and pharmaceutically acceptable salts thereof, have excellent antimicrobial activity against a broad spectrum of microorganisms including Gram-negative bacteria such as Escherichia coli, Serratia marcescens, Proteus rettgeri, Enterobacter cloacae, Citrobacter freundii. Thus, these compounds may be used as antibacterial agents for therapeutic purposes.
Claims10
A compound of the formula:
- ##STR21## wherein R.sup.1 is hydrogen;
- R.sup.2 is chloro, methoxy or methylthio and R is hydrogen or pivaloyloxymethyl and pharmacologically and pharmaceutically acceptable salts thereof.
A compound of the formula ##STR22## wherein B.sub.1 is selected from the group consisting of chloro, methoxy or alkylthio of 1 to 4 carbon atoms;
- B.sub.3 is selected from the group hydrogen, pharmaceutically acceptable salts and ester forming groups.
Dependencies are inferred from the claim text.