Enkephalin degrading enzyme inhibitors
AssigneeAmerican Home Products Corporation
InventorsDimitrios Sarantakis, William Dvonch
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Abstract
Compounds which inhibit the brain enzyme degradation of enkephalins and which exhibit their own analgesic effect, having the formula ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; X is hydrogen, hydroxy, halo, nitro, amino or lower alkoxy; R.sub.2 is hydrogen or ##STR2## wherein R.sub.3 is lower alkyl and R.sub.4 is L- or D-Thz or Pro, and the pharmaceutically acceptable salts thereof.
Claims2
A method for inhibiting brain enzyme degradation of enkephalins which comprises administering to a mammal an amount sufficient to inhibit the brain enzyme degradation of said enkephalins of a compound of the formula:
- ##STR6## wherein R.sub.1 is hydrogen or lower alkyl;
- X is hydrogen, hydroxy, halo, nitro, amino or lower alkoxy;
- R.sub.2 is hydrogen or ##STR7## wherein R.sub.3 is lower alkyl and R.sub.4 is L- or D-Thz or Pro and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.