Solid drug preparations
AssigneeYamanouchi Pharmaceutical Co., Ltd.
InventorsMuneo Fukui, Yutaka Konno, Yukio Kubota, Masayoshi Aruga, Hiroitsu Kawata
Life of this patent
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Abstract
A solid microdose drug preparation containing a microdose drug such as formoterol fumarate or .beta.-methyldigoxin coated with wax. In the drug preparation, the stability and the content uniformity of the microdose drug have been improved.
Claims14
In a solid pharmaceutical composition containing less than 5 mg/dosage unit of a powdered microdose drug subject to changes in crystal form stability selected from the group consisting of gidoxin, digitoxin, .beta.-methyl-digoxin, formoterol fumarate, procathelol, dexamethasone, .beta.-methasone, nitroglycerin, reserpine, folic acid, cobamide, ethynylestradiol, hexoprenaline, polythiazide, diethylstilbestrol, cortisone, ergotamine, and ergometrine, the improvement comprising said powdered microdose drug being coated with a hydrophobic wax by the method comprising uniformly dispersing a powder of a microdose drug directly in molten wax and forming a powder or granule of the dispersion, or dispersing a powder of a microdose drug in a hydrophobic wax dissolved in a solvent, removing the solvent and forming a powder or granule of the residue, whereby said powdered microdose drug is stabilized against changes in crystallinity and against losses due to electrostatic charge or stickiness.
Dependencies are inferred from the claim text.