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US 4,379,933 AGranted
Process for preparing spiro[indoline-3,4'-piperidine]s
AssigneeAmerican Hoechst Corporation
InventorsHelen H. Ong, James A. Profitt
Life of this patent
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Abstract
Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.
Claims3
A method for preparing a compound of the formula ##STR26## or a physiologically acceptable salt thereof in which Y is ##STR27## R.sup.1 is hydrogen or loweralkyl;
- R.sup.2 and R.sup.3 are the same or different and each can be hydrogen, halogen, trifluoromethyl, loweralkyl, loweralkoxy, hydroxy, nitro, amino, formamido or acetamido;
- X is hydrogen, halogen, loweralkyl, loweralkoxy or hydroxy, which comprises treating a 1'-methylspiro[indoline-3,4'-piperidine] of the formula ##STR28## in which X and R.sup.1 are as defined above with a fluorophenyl of the formula ##STR29## in which R.sup.2' and R.sup.3' are the same or different and each can be hydrogen, halogen, trifluoromethyl, loweralkyl, loweralkoxy or nitro in the presence of a solvent and a base.
Dependencies are inferred from the claim text.