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US 4,379,929 AGranted
4(1H)-Oxocinnoline-3-carboxylic acid derivatives
AssigneeEli Lilly and Company
InventorsRobert A. Conrad, William A. White
Life of this patent
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Abstract
Amide and ester derivatives of substituted-4(1H)-oxocinnoline-3-carboxylic acids have antibacterial activity and are useful for inhibiting the growth of disease causing bacteria.
Claims12
Compound of the formula ##STR8## wherein R represents methylenedioxy, or nitro;
- m=1;
- R.sup.1 represents C.sub.1 -C.sub.3 alkyl, n-butyl, or allyl;
- R.sup.2 represents hydroxy C.sub.2 -C.sub.4 alkoxy, NHCH.sub.2 CH.sub.2 OH, NHCH.sub.2 CH.sub.2 SH, NHCH.sub.2 COOH, NHCH.sub.2 CH.sub.2 NH.sub.2, ##STR9## subject to the limitation that when R represents nitro, R.sup.2 represents NHCH.sub.2 CH.sub.2 SH;
- and wherein the position of R on the cinnoline ring is as follows:
- 1. when R represents methylenedioxy, R is at the 6,7-position of the cinnoline ring, or
- 2. when R represents nitro, R is at the 7-position of the cinnoline ring.
3 more elements
Dependencies are inferred from the claim text.