1,4,5,6-Tetrahydropyrimidine derivatives
AssigneeAyerst McKenna and Harrison Ltd.
InventorsJean A. Gauthier, Ivo Jirkovsky
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Abstract
1,4,5,6-Tetrahydropyrimidine derivatives characterized by having a phenyl or substituted phenyl at positions 1 and 6 in addition being further substituted at position 2. The foregoing compounds are useful as diuretic agents in a mammal. Methods for the preparation and use of the compounds are disclosed.
Claims12
A compound of formula I ##STR3## in which R.sup.1 and R.sup.2 are phenyl and R.sup.3 is lower alkyl, phenyl, 2-furyl, 3-pyridinyl, 2-thienyl, di(lower alkyl)amino or a radical of formula R.sup.4 --A wherein A is lower alkylene and R.sup.4 is 1-piperidinyl or 4-morpholinyl;
- or a therapeutically acceptable acid addition salt thereof.
A compound of formula I ##STR4## in which R.sup.1 and R.sup.2 are phenyl and R.sup.3 is lower alkyl, phenyl or di(lower alkyl)amino;
- or a therapeutically acceptable acid addition salt thereof.
A compound of formula I ##STR5## in which R.sup.1 and R.sup.2 are phenyl and R.sup.3 is 2-furyl, 3-pyridinyl, 2-thienyl or a radical of formula R.sup.4 --A wherein A is lower alkylene and R.sup.4 is 1-piperidinyl or 4-morpholinyl;
- or a therapeutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.