Polymeric compositions and hydrogels formed therefrom
AssigneeSyntex (U.S.A.) Inc.
InventorsPaul M. Gallop, Donald R. Korb
Life of this patent
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Abstract
The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.
Claims33
A hydrogel comprising of hydrophilic polymer comprising the polymerization product of:
- a first monomer comprising a dihydroxyalkyl acrylate or dihydroxyalkyl methacrylate,
- a second monomer comprising a substantially water insoluble alkyl acrylate or alkyl methacrylate, the mole ratio of said first monomer to said second monomer varying within the range from about 1:3 to about 20:1;
- a third monomer comprising a compound selected from the group consisting of:
- ##STR10## where R.sup.3 is hydroxyl, alkoxy having 1 to 6 carbon atoms, a sulfonic acid moiety, ##STR11## wherein R.sup.4 and R.sup.5 are independently selected from the group consisting of hydrogen and an unsubstituted or substituted alkyl group having from 1 to about 3 carbon atoms, or R.sup.4 and R.sup.5 may be combined to form a cyclic group, and n is an integer from 0 to about 4, except that n must be at least 1 when R.sup.3 is hydroxyl;
- ##STR12## where R.sup.6 is hydroxyalkoxy having 1 to 6 carbon atoms or --NR.sup.7 R.sup.8 where R.sup.7 and R.sup.8 are independently selected from hydrogen and lower alkyl groups having 1 to 4 carbon atoms;
- ##STR13## where R.sup.9 is hydroxyalkoxy having from 1 to about 6 carbon atoms or vinyl acetate;
- and
- (d) mixtures thereof:
- the total of the molar quantities of said first and second monomers to the molar quantity of said third monomer being in the range of 1:1 to 1:0.2,
- which is substantially hydrated with water.
A hydrogel comprising a hydrophilic polymer comprising:
- a first monomer comprising a hydrophilic compound having the formula:
- ##STR16## wherein:
- R is hydrogen or methyl;
- and
- n is an integer from 1 to 4;
- a second monomer comprising a substantially insoluble acrylate or methacrylate selected from the group consisting of methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, propyl acrylate, propyl methacrylate, isopropyl acrylate, isopropyl methacrylate, butyl acrylate, and butyl methacrylate, the mole ratio of said first monomer to said second monomer varying within the range from about 1:3 to about 20:1;
- and
- a third monomer selected from the group consisting of vinyl acetate, 3-buten-1-ol, 2-propen-1-ol, 5-hexenol, methyl vinyl ether, propyl vinyl ether, butyl 3-buten-1-ol ethyl, N-methyl vinyl amide, N-propyl vinyl amide, N-ethyl-3-butenamide, vinyl pyrrolidone, 3-hydroxypropyl acrylate, 2-hydroxyethyl acrylate, 2-hydroxyethyl methacrylate, methacrylamide, N-methyl methacrylamide, N,N-dimethyl methacrylamide, and mixtures thereof:
- the total of the molar quantities of said first and second monomers to the molar quantity of said third monomer being in the range of 1:1 to 1:02, which is subsequently hydrated with water.
Dependencies are inferred from the claim text.