Anti-inflammatory composition

A pharmaceutical composition useful for treating inflammation containing (i) a renal vasodilator compound of the formula ##STR5## wherein R is carboxy, a carboxy salt, a carboxy ester of the formula COOR.sup.5 wherein R.sup.5 is C.sub.1-10 alkyl,, or CONHR.sup.6 wherein R.sup.6 is amino or methylsulfonyl;

• A is a p-phenylene or a m-phenylene or substituted phenylene derivative in which one or two of the phenylene hydrogens is replaced by a methyl or a halo substituent;
• n is 3 or 4;
• m is 0, 1, or 2;
• R.sup.1 is hydrogen, deuterium, or methyl;
• Z is alkylene or unsaturated alkylene having from 2-3 carbon atoms;
• R.sup.2 is hydrogen or lower alkanoyl;
• R.sup.3 is hydrogen or straight chain C.sub.1-3 alkyl;
• and
• R.sup.4 is lower straight chain or branched alkyl having from 3-7 carbon atoms, an unsaturated alkyl having from 3-7 carbon atoms, or a substituted lower alkyl selected from polyfluoro alkyl of from 3-7 carbon atoms and lower alkoxy methylene;
• or
• R.sup.3 and R.sup.4 taken together with the carbon atom connecting R.sup.3 and R.sup.4 is a cyclic substituent selected from a bridged or unbridged alicyclic ring of from 5-9 carbon atoms or a heterocyclic ring containing sulfur or oxygen and from 5-7 ring-forming carbon atoms. and (ii) inclomethacin wherein the weight ratio i:ii ranges from 1.7:1 to 1:26.