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US 4,379,790 AGranted
(Erolinyl)-N,N-diethylurea derivatives, and their preparation and use
AssigneeSchering Corporation
InventorsReinhard Horowski, Wolfgang Kehr, Gerhard Sauer, Ulrich Eder, Hans P. Lorenz
Life of this patent
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Abstract
Compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is alkyl of 2-6 carbon atoms, ##STR2## n is 1, or 2, m is 0 or 1, R.sub.2 is alkyl of 1-6 carbon atoms, ##STR3## is a CC single bond or a CC double bond, and the 8-positioned urea residue can be in the .alpha.- or .beta.-position, have valuable pharmacological properties, e.g., lactation inhibition and anti-Parkinsonism.
Claims39
An ergolinyl-N',N'-diethylurea of the formula ##STR7## or a pharmaceutically acceptable salt thereof, wherein
- R.sub.1 is alkyl of 2-6 carbon atoms, alkyl of 2-6 carbon atoms substituted by ##STR8## n is 1, or 2, m is 0 or 1,
- R.sub.2 is alkyl of 1-6 carbon atoms, ##STR9## is a CC single bond or a CC double bond, and the 8-positioned urea residue can be in the .alpha.- or .beta.-position.
Dependencies are inferred from the claim text.