Oximino-substituted cephalosporin compounds
AssigneeEli Lilly and Company
InventorsWilliam H. W. Lunn, William J. Wheeler
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Abstract
Broad spectrum cephalosporin antibiotics represented by the formula ##STR1## wherein R is an amino-substituted oxazole, oxadiazol, or isoxazole heterocyclic, R' is C.sub.1 -C.sub.4 alkyl, a carboxysubstituted alkyl or cycloalkyl group, etc., and .sup..sym. R.sub.1 is an oximino-substituted pyridinium, quinolinium or isoquinolinium group, e.g., .sup..sym. R.sub.1 is a 3- or 4-formylpyridinium oxime group; pharmaceutical compositions comprising the antibiotic, and a method for treating antibacterial infections are provided.
Claims23
A compound of the formula ##STR32## wherein R is an amino-substituted heterocyclic of the formula ##STR33## R' is hydrogen, C.sub.1 -C.sub.4 alkyl, a carboxy-substituted alkyl or a carboxy-substituted cycloalkyl group of the formula ##STR34## wherein a and b when taken separately are independently hydrogen or C.sub.1 -C.sub.3 alkyl, and a and b when taken together with the carbon atom to which they are bonded form a C.sub.3 -C.sub.7 carbocyclic ring;
- n is 0-3;
- and R" is hydroxy, C.sub.1 -C.sub.4 alkoxy, amino OR.degree., wherein R.degree. is a carboxy-protecting group, R' is a carbamoyl group of the formula ##STR35## wherein R"' is C.sub.1 -C.sub.3 alkyl, phenyl, or C.sub.1 -C.sub.3 alkyl substituted by phenyl;
- .sup..sym. R.sub.1 is an oximino-substituted pyridinium, quinolinium, or isoquinolinium group represented by the formulas ##STR36## wherein R.sub.2 and R.sub.3 independently are hydrogen or C.sub.1 -C.sub.3 alkyl;
- and the pharmaceutically acceptable non-toxic salts thereof.
Dependencies are inferred from the claim text.