N-Aryl-N-(4,5,6,7-tetrahydro-1H-1,3, diazepin-2-yl)ureas as antihypertensives
AssigneeMcNeilab, Inc.
InventorChris R. Rasmussen
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Abstract
N-(Substituted phenyl)-N'-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl)ureas, and pharmaceutically-acceptable salts thereof, are disclosed, as are compositions containing said ureas in a pharmaceutically-acceptable carrier, to have antihypertensive activity and to be useful in a method of reducing arterial pressure in hypertensive subjects.
Claims6
A method of reducing arterial pressure in a hypertensive animal which comprises administering to said hypertensive animal, a therapeutically-effective antihypertensive amount of a compound selected from the group consisting of
- (a) an N-aryl-N'-(4,5,6,7-tetrahydro-1H-1,3,-diazepin-2-yl)urea having the formula:
- ##STR8## wherein X is Br, Cl, F, CH.sub.3, CF.sub.3 or OCH.sub.3 ;
- Y is H, Br, Cl, F, CH.sub.3, CF.sub.3 or OCH.sub.3 ;
- and Z is H or F;
- and
- (b) a pharmaceutically-acceptable salt thereof.
A method of reducing arterial pressure in hypertensive subjects which comprises administering to a hypertensive subject from about 1 to about 500 milligrams per unit dose of an N-aryl-N'-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl)urea compound represented by the formula:
- ##STR9## wherein X and Y are each independently selected from the group consisting of Br, Cl, CH.sub.3 and CF.sub.3 ;
- or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.