Pyrazolobenzazepines
AssigneeHoffmann-La Roche Inc.
InventorsGeorge F. Field, Rodney I. Fryer, Eugene J. Trybulski, Armin Walser
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Abstract
There are presented compounds of the formulas ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, lower alkyl, C.sub.2 to C.sub.7 carboxylic acids, hydroxy C.sub.2 to C.sub.7 alkyl, C.sub.2 to C.sub.7 carboxylic acid esters and amides and the group COR.sub.11 wherein R.sub.11 is alkoxy, amino or mono- lower alkyl amino; R.sub.6 is nitro or halo and R.sub.5 is hydrogen or halo, and the pharmaceutically acceptable salts thereof. The pyrazolobenzazepines are useful as anxiolytic and sedative agents. Also provided are processes and intermediates in the production of the above pyrazolobenzazepines.
Claims6
A compound of the formula ##STR9## wherein R.sub.1 is hydrogen or lower alkyl;
- R.sub.2 is selected from the group consisting of hydrogen, lower alkyl, C.sub.2 to C.sub.7 carboxylic acids, hydroxy C.sub.2 to C.sub.7 alkyl, C.sub.2 to C.sub.7 carboxylic acid esters and amides and the group COR.sub.11 wherein R.sub.11 is alkoxy, amino or mono-lower alkyl amino;
- R.sub.6 is nitro or halo and R.sub.5 is hydrogen or halo
- and the pharmaceutically acceptable salts thereof.
A compound of the formula ##STR10## wherein R.sub.1 is hydrogen or lower alkyl;
- R.sub.3 is selected from the group consisting of hydrogen, lower alkyl, C.sub.2 to C.sub.7 carboxylic acids, hydroxy C.sub.2 to C.sub.7 alkyl, C.sub.2 to C.sub.7 carboxylic acid esters and amides and the group COR.sub.11 wherein R.sub.11 is alkoxy, amino or mono-lower alkyl amino;
- R.sub.6 is nitro or halo and R.sub.5 is hydrogen or halo
- and the pharmaceutically acceptable salts thereof.
The compound:
- 8-Chloro-6-(2-fluorophenyl)-2H,4H-pyrazolo[3,4-d][2]benzazepine.
The compound:
- 8-Chloro-6-phenyl-2-(2-hydroxyethyl)-2H,4H-pyrazolo[3,4-d][2]benzazepine.
The compound:
- 6-(2-Chlorophenyl)-3-methyl-8-nitro-2H,4H-pyrazolo[3,4-d][2]benzazepine.
The compound:
- 8-Chloro-2-[(methylamino)carbonyl]-6-phenyl-2H,4H-pyrazolo[3,4-d][2]benzaz epine.
Dependencies are inferred from the claim text.