Reaction apparatus for the formation of microspheres or microcapsules
AssigneeOrtho Diagnostics, Inc.
InventorsPeter J. Natale, Igino Lombardo
Life of this patent
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Abstract
A core/sheath vibrating system is utilized to produce core droplets within the sheath, which in turn form into microparticles through phase separation. The flow momentum is first arrested by means of an inclined surface, and the combination is thence deposited, in a continuous, helical channel extending from one end to the other of the inside of a hollow, rotating drum. Rotation of the drum moves the forming microspheres through the channel. At the exit end of the drum, the sheath fluid which carries suspended microspheres, may be filtered, and the microspheres collected and utilized.
Claims5
Microparticle formation apparatus for use in a system of microparticle formation from a flowing stream of a core liquid ejected from the exit of a vibrating nozzle concurrently and coaxially into a flowing stream of a sheath liquid forming a composite liquid stream wherein droplets formed of said core liquid within said sheath liquid are formed into microparticles, said formation apparatus further comprising:
- (a) a drum having a substantially horizontal longitudinal axis therethrough, said drum defining an inlet end and an outlet end and forming a cavity between said inlet and outlet ends, and an internal spiral channel means extending between said inlet and outlet ends;
- (b) mixing means intermittently spaced within said channel means to provide turbulence in the flow of said composite liquid stream from said inlet end to said outlet end;
- and
- (c) means for rotating said drum about said longitudinal axis.
Formation apparatus for use in a system for generating microparticles by injecting a first material into a moving sheath material, and by forming droplets in said sheath material with said first material upon ejection from a vibrating nozzle, said microparticles being formed by phase separation between said first material and said sheath material, said formation apparatus comprising:
- a hollow cylindrical drum having a continuous helical trough therein from one end to the other;
- mixing means in said helical trough for providing turbulence;
- means for depositing said sheath and droplets into said trough at one end of said drum;
- means for rotating said drum;
- and means for collecting microparticles from said trough at said other end of said drum.
Dependencies are inferred from the claim text.