Back to results
US 4,379,166 AGranted
Arylmethoxy-, arylmethylthio-, heteroarylmethoxy-, and heteroarylmethylthio-alkylaminoalcohols
AssigneeSchering Corporation
InventorsBernard R. Neustadt, Elijah H. Gold
Life of this patent
Estimating the term…
Abstract
This invention relates to 5-(2-alkylamino-1-hydroxyethyl)salicylamides and 4-(2-alkylamino-1-hydroxyethyl)-2-(methylsulfinyl)phenols wherein the alkyl group is substituted by arylmethoxy, arylmethylthio, heteroarylmethoxy, or heteroarylmethylthio, pharmaceutical compositions thereof, and their use as cardiovascular agents.
Claims14
A compound of the formula ##STR10## wherein X is carbamoyl, mono- or di- C.sub.1 to C.sub.6 alkyl carbamoyl, C.sub.1 to C.sub.6 alkylthio, C.sub.1 to C.sub.6 alkylsulfinyl, or C.sub.1 to C.sub.6 alkylsulfonyl;
- Y is O, S, SO or SO.sub.2 ;
- and
- R is phenyl;
- phenyl substituted by C.sub.1 to C.sub.6 alkyl, hydroxy, C.sub.1 to C.sub.6 alkoxy, halo, carboxy, C.sub.1 to C.sub.6 alkoxycarbonyl, or nitro groups;
- heteroaryl groups having 5 to 10 ring members having one or two rings comprising aromatic carbon atoms and from 1 to 3 nitrogen atoms, and substituted derivatives thereof wherein said heteroaryl group is substituted by C.sub.1 to C.sub.6 alkyl, hydroxy, C.sub.1 to C.sub.6 alkoxy, halo, phenyl, or C.sub.1 to C.sub.6 alkoxycarbonyl, and wherein said heteroaryl group is joined to the side chain at one of said ring aromatic carbon atoms;
- and the pharmaceutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.