US 4,379,161 A · Novel substituted heterocyclic phenoxyamines, the method of preparation thereof and the use thereof as local anaesthetics

Abstract

The present invention concerns substituted heterocyclic phenoxyamines having the following formula: ##STR1## their pharmacologically acceptable acid salts, their quaternary ammonium salts, their N-oxides, their levorotatory and dextrorotatory isomers and the processes for the preparation thereof. In the above formula: m=0 or 2 n=0 or 2 provided that m+n=2 A represents hydrogen, a lower alkoxy or lower alkenyloxy group, X represents a halogen, R represents hydrogen or a saturated or unsaturated aliphatic and/or cyclic hydrocarbon radical such as in particular lower alkyl, lower alkenyl, cycloalkyl and cycloalkyl-alkyl, cycloalkenyl and cycloalkenyl-alkyl. The compounds of the invention are useful as local anaesthetics.

Claims24

Dependent claims

A heterocyclic phenoxy-amine of the formula ##STR8## where m is 0 or 2, n is 0 or 2, and m+n is 2;

where
X is F, Cl or Br;
where
A is hydrogen or alkoxy of 1 to 4 carbon atoms;
and
where
R is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, cycloalkenyl of 4 to 6 carbon atoms, or cycloalkenyl-alkyl or cycloalkyl-alkyl with the cycloalkenyl, cycloalkyl and alkyl groups having 4 to 6 carbon atoms, 3 to 6 carbon atoms and 1 to 6 carbon atoms respectively.

4 more elements

Dependencies are inferred from the claim text.

Novel substituted heterocyclic phenoxyamines, the method of preparation thereof and the use thereof as local anaesthetics

Life of this patent

Novel substituted heterocyclic phenoxyamines, the method of preparation thereof and the use thereof as local anaesthetics

Life of this patent

Abstract

Claims24