Carbazole compounds and medicinal use thereof
AssigneeBurroughs Wellcome Co.
InventorsMorton Harfenist, Charles T. Joyner
Life of this patent
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Abstract
This invention is directed to a carbazole compound 9-[3-(3,5-cis-dimethylpiperazino)propyl]carbazole, its salts, especially pharmaceutically acceptable salts, and solvates such as hydrates, alcoholates of the salts thereof as well as pharmaceutical compositions containing same which are useful in treating aggression and/or psychoses in humans.
Claims38
A pharmaceutical composition for use in treating aggression or psychosis or both which comprises an effective non-toxic antiaggression amount or an effective non-toxic antipsychosis, or an effective amount for treating both aggression and psychosis of a compound 9-[3-(3,5-cis-dimethylpiperazino)propyl] carbazole, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate of a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor.
A pharmaceutical preparation in dosage unit form adapted for administration to obtain an anti-aggressive effect or an anti-psychosis effect, comprising per dosage unit, an anti-aggressive or anti-psychosis effective nontoxic amount of a compound 9-[3-(3,5-cis-dimethylpiperazino) propyl] carbazole, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate of a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent.
A pharmaceutical composition in dosage unit form adapted for administration to a human to obtain a therapeutic effect comprising from about 10 to 900 mg of a compound 9-[3-(3,5-cis-dimethylpiperazino)propyl] carbazole, or a pharmaceutically acceptable salt thereof and a pharmaceutical diluent.
The method of treating aggression in a human which has been identified as exhibiting aggressive symptoms which comprises administering to said human an effective nontoxic antiaggression amount of 9-[3-(3,5-cis-dimethylpiperazino)propyl]-carbazole, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of a pharmaceutically acceptable salt thereof.
The method of treating psychosis in a human which has been identified as exhibiting psychotic symptoms which comprises administering to said human an effective nontoxic antipsychotic amount of 9-[3-(3,5-cis-dimethylpiperazino)propyl]carbazole, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of a pharmaceutically acceptible salt thereof.
Dependencies are inferred from the claim text.