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US 4,379,159 AGranted
Antiinflammatory 2-substituted-thio-4,5-dihydro-4,5-diaryl-1H-imidazoles
AssigneeE. I. Du Pont de Nemours and Company
InventorSaul C. Cherkofsky
Life of this patent
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Abstract
Antiinflammatory 2-substituted-thio-4,5-dihydro-4,5-diaryl-1H-imidazoles, such as 4,5-bis(4-chlorophenyl)-4,5-dihydro-2-(2,2,2-trifluoroethylthio)-1H-imidaz ole hydrochloride, useful for treatment of arthritis and related diseases.
Claims15
A compound of the formula ##STR5## where R.sub.1 =C.sub.1 -C.sub.4 alkyl, mono- or polyfluoro C.sub.2 -C.sub.4 alkyl with the proviso that a fluoro group cannot be present in the .alpha. position, or allyl;
- R.sub.2 and R.sub.3 independently= ##STR6## where X=H, F, Cl, Br, NO.sub.2 or CH.sub.3 S(O).sub.n ;
- n=0, 1 or 2;
- Y=H, F or Cl;
- provided when Y=F or Cl, X must be F or Cl, and provided R.sub.2 and R.sub.3 cannot both be phenyl;
- or a pharmaceutically suitable acid addition salt thereof.
2 more elements
Dependencies are inferred from the claim text.