Analgesic and anti-inflammatory composition
AssigneeMorishita Pharmaceutical Co., Ltd.
InventorsMakoto Sato, Isami Kimura, Azuma Yamaguchi
Life of this patent
Estimating the term…
Abstract
An analgesic and anti-inflammatory composition containing emorfazone (4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone) and a non-steroidal acidic anti-inflammatory agent such as phenylbutazone, ibuprofen, mefenamic acid, indomethacin, acetylsalicylic acid, naproxen, ketoprofen and flurbiprofen.
Claims4
An analgesic and anti-inflammatory pharmaceutical composition for oral administration comprising an analgesic and anti-inflammatory effective amount of a combination of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone and a non-steroidal acid anti-inflammatory agent selected from the group consisting of phenylbutazone, ibuprofen, mefenamic acid, indomethacin, acetylsalicylic acid, naproxen, ketoprofen and flurbiprofen, said composition comprising about 1/4 to 1/2 of the oral clinically effective amount of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone and about 1/3 to 1/2 the oral clinically effective amount of the non-steroidal acid anti-inflammatory agent.
A process for potentiating the pharmacological effect of a non-steroidal acid anti-inflammatory agent selected from the group consisting of phenylbutazone, ibuprofen, mefenamic acid, indomethacin, acetylsalicylic acid, naproxen, ketoprofen and flurbiprofen, when administered to a subject which comprises orally administering a therapeutically effective amount of a combination of said non-steroidal acidic anti-inflammatory agent with a potentiating effective amount of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone, said combination comprising about 1/4 to 1/2 of the oral clinically effective amount of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone and about 1/3 to 1/2 the oral clinically effective amount of the non-steroidal acidic anti-inflammatory agent.
Dependencies are inferred from the claim text.